Buffout is a consumable item in Fallout 3 and Fallout: New Vegas.
Buffout is a highly advanced steroid that was popularized before the Great War by professional athletes and their clandestine use of the drug.
Buffout is a consumable performance enhancing drug, that boosts both Strength and Endurance, in addition to a health increase of +60 Hit Points. After four minutes the effects wears off and you will lose 60 Hit Points from your current total; if you have less than 60 health when it wears off your total health will be reduced to 1.
Addiction can occur when using this chem and can only be removed by a visit to the doctor or by the temporary effects of Fixer. It carries a 10% addiction rate.
 Fallout 3
Although many vendors will have one or two doses, significant quantities of Buffout are sold by:
 Fallout: New Vegas
 Related quests
In Fallout: New Vegas, Buffout is needed for the Fallout: New Vegas side quest High Times.
To help Jacob Hoff kick his addiction, the character will need a Speech level of 50 - or a Science level of 50 and Fixer (1), psycho (1), and Buffout (1). If the character's Speech and Science levels are too low Fixer (10) will be needed.
- If you look carefully at bottles of Buffout, you'll see that the icon for Buffout in Fallout 1 and 2 is integrated into the labeling of the item. Printed on theses bottles are lengthy usage instructions and an expiration date of 10/13.
- Taking stimpaks while the Buffout health bonus is active will use your stimpaks even if you are at full health.
- If you attempt to use the status tab to heal yourself, you can't gain the extra 60HP afforded by the chem. However, if you use stimpaks or other healing items in the inventory-aid panel, you can gain the full 60HP.
- ↑ Fallout 2 Official Strategies & Secrets p.72: "Originally made popular through clandestine use by professional athletes, Buffout is particularly helpful in mêlée or unarmed combat."