The Eastern Commonwealth was one of the thirteen commonwealths of the pre-war United States of America. Created in the early 21st century, it was comprised of the former states of West Virginia, Delaware, Pennsylvania, New Jersey and New York.
 Capital Wasteland
West Virginia is a part of the Capital Wasteland.
Philly, once reminisced by Abraham Washington, was the post-War ruins of the city of Philadelphia. Mass radiation, raiding, slavery, not a place for the wisest wasteland traveler to explore. The Pitt, the pre-War city of Pittsburgh, shows us just a glimpse of Philly life, where a cure for radiation is being researched.
The Philly is also the location where the mythical Liberty Bell sits & waits for Washington's expedition to find it and put it in the museum, where it belongs.
 Great Lanta
What used to be Atlantic City in New Jersey was the birthplace of Saint Monica. Later on in Saint Monica's life, slavers invaded Great Lanta and occupied the region. The leader of one slaver group, Ehran, realised his wrongdoing and freed his slaves. As of 2277, it is unknown if the slavers remain.
 Known places
 New York
- Albany terrorist prison (mentioned in Point Lookout)
- New York City (mentioned in the Fallout Bible 0, Fallout 3 and Dead Money)