Slavery is a lucrative business in the post-Great War world. Although many of the larger pockets of civilization have outlawed slavery, the practice persists throughout the wasteland.
Slavery is a controlled business in the post-nuclear world. Nearly all the slave trade in New California is done under the auspices of the Slaver's Guild, a group of older slavers who decide prices and organize capture hunts in the wastelands. Anyone caught capturing or selling slaves in the Core Region without their blessing may be forced to undergo a series of trials until either deemed worthy to join the Guild or killed. The Guild often controls smaller towns in which it operates, although quietly—preferring to remain behind the scenes. Guild members wear a distinctive tattoo covering most of their face, making them readily identifiable and allowing the Guild to make fast judgments when someone without "the tat" has a tribal up on the auction block.
Slavers in the Fallout games do not discriminate between people based upon their race, species, or ideology; anyone who can be easily cowed into submission, captured, and fitted with a slave collar is perfectly acceptable "meat" for them to use. Similarly, slavers themselves may be of any ethnic background.
 Fallout 2
Fallout 2 is peppered with slavers, most notably in The Den. The Chosen One is able to join the slavers for extra cash, but his/her karma will take a beating, and he/she will be branded permanently as a member of the Slaver's Guild, which may negatively impact the reactions of certain NPCs.
There is also a large slave-holding pen on the NCR/Northern California border run by a slaver named Vortis. Although there is frequent conflict between the slavers and the NCR Rangers, Vortis probably profits off of all the caravans who are known to purchase slaves as porters and sell them off at the end of their journeys. Some random encounters feature slavers as well as slaves, often together. If the player is a member of the NCR Rangers or killed Metzger, slavers will act more aggressively towards the player.
 Fallout 3
Slavers play a fairly large role in Fallout 3. Paradise Falls is the slaver headquarters in the Capital Wasteland with Eulogy Jones as its leader. Several quests feature slavery as either major or minor elements, most notably Head of State and its association to slavery and Abraham Lincoln's role as the 'Great Emancipator.' Additionally, the Lone Wanderer can capture people to sell them to slavers. The Lone Wanderer can even buy a slave, Clover, who will then serve the player as a bodyguard. The player does not have the option of activating the explosive collar of Clover. The number of slaves present compared to the number of slavers is remarkably low, showing that the slaves are being shipped off somewhere. It is revealed by Wernher that many of these slaves are shipped off to work at the Pitt.
 Fallout: New Vegas
In Fallout: New Vegas, Caesar's Legion is the primary slaving "company" that enslaves any survivors of their pillages that aren't deemed "worthy" of death. Many legion slaves can be found at The Fort carrying heavy loads on their backs as well as working to keep the Legionaries fed and healthy. It is also implied that sexual abuse at the hands of the legionnaires happens to the slaves on a regular basis. Occasionally, if a slave gets mouthy or refuses orders, they are sent to the Arena where they fight challengers to the death.