The army fled to the east after the death of the Master and the destruction of Mariposa Military Base, pursued by Brotherhood of Steel airships. While most of these ended up in the vicinity of Chicago, far from Gammorin's forces, one of the zeppelins crashed north of the mutant encampment. The leader, Paladin Latham, challenged Gammorin to single unarmed combat and, to surprise of everyone, killed the mighty mutant. As he defeated the previous chieftain, the super mutants expected him to become the new leader of their army, which he did with his mental health compromised by a head injury sustained in the fight.
The game takes place in 2197 in the American Midwest. The Eastern Brotherhood of Steel is trying to claim territory surrounding Chicago. The Warrior, the player character, is a new recruit to the Brotherhood, tasked to lead a squad of soldiers made up of available initiates.
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