A little cafe overlooking a back street, Anna's Cafe provided local citizens with Sicilian espresso, food, and gave an opportunity to rest on the way through the city. The War and the passage of time did the Cafe no favors. The upper floor is in shambles, with the skeleton of the owner by the ruined bed, still clutching the 10mm pistol they shot themselves with, unable to cope with the grief. There's a lone lunchbox under the desk. On top of the building that contains the cafe is another skeleton, with drugs and remnants of a Buttercup nearby.
- Vault-Tec lunchbox underneath desk on second floor.
Anna's Cafe appears only in Fallout 4.