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Bruce may refer to:
- Bruce Isaac, a singer from New Reno in Fallout: New Vegas.
- Bruce, a spurned lover mentioned in Fallout: New Vegas.
- Bruce Richardson, an American soldier who fought and died during the Yangtze Campaign, mentioned in Fallout: New Vegas.
- Bruce - a guest at and friend of Jim and Jess' wedding, mentioned in the Fallout 4 add-on Far Harbor.
- Real-life people