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Caleb may refer to:
- Caleb - leader of the Regulators in Fallout.
- Caleb Smith - the stonemason of the Temple of the Union in Fallout 3.
- John-Caleb Bradberton - the inventor of Nuka-Cola and founder of the Nuka-Cola Corporation, mentioned in Fallout 3.
- Caleb McCaffery - an ex-casino enforcer in Fallout: New Vegas.
- Caleb Truman, one of the initial resident subjects of Vault 75 in Fallout 4.
- Caleb - one of the initial player characters in the canceled Fallout Extreme.
- Real-life people