Elizabeth Chambers was a Vault 51 dweller who perished under ZAX's rule. Wife of state senator Joel Chambers, Elizabeth was given a place at Vault 51 alongside her husband. Although she supported her husband's initial bid for leadership, his indiscretions and romance with Carmen Greene eventually led her to strike out on her own. An innocuous suggestion that she should look after her health led to an affair with Matthew Johnston, a personal trainer in the Vault.
In August, things came to a head. ZAX engineered a confrontation between them and their lovers, putting the four of them in one room and letting them kill one another: Elizabeth strangled Carmen, Joel's lover, Joel shot Matthew, Elizabeth's lover, and then the Chambers murdered each other.
Elizabeth Chambers is mentioned only in Fallout 76.