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Francis may refer to:
- Sister Francis, a member of the Children of the Cathedral in Fallout.
- Francis, a Broken Hills super mutant in Fallout 2.
- Francis Allen, soldier who fought and died during the Yangtze Campaign, mentioned in Fallout: New Vegas.
- Francis Lipsett, soldier who fought and died during the First Battle of Hoover Dam, mentioned in Fallout: New Vegas.
- Francis Smith, a Lieutenant Colonel of the British Army during the American Revolutionary War, mentioned in Fallout 4.
- Elder Francis, a Brotherhood of Steel member mentioned in The Armageddon Rag, Vol. 3.