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|For the employee of the Vault-Tec Corporation mentioned in Fallout 4, see Henderson (Fallout 4).|
Little is revealed in game of Henderson. He attended college where he got a degree in robotics before getting a job at the H&H Tools factory. The paranoid owner of the factory, Anthony House, was afraid that Henderson and Robert House were planning to seize the company away from him. Anthony asked Cindy-Lou Kreb to keep an eye on Henderson for him, going as far as to monitor his e-mails to check for suspicious activity.
Henderson's fate is left unknown, however it can be assumed that he was killed when Anthony House initiated the H&H Tools factory security system, which caused the death of most (if not all) of the employees. 
Henderson is mentioned only in Fallout: New Vegas.