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Jacob may refer to:
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- Jacob (Fallout) - One of the Brotherhood of Steel Elders in Fallout.
- Jacob (Paladin) - a Brotherhood of Steel Paladin, and the human co-founder of Broken Hills in Fallout 2.
- Jacob the Chemist - a citizen of Broken Hills in Fallout 2.
- Jacob Humboldt - a character in Fallout 3 add-on in Point Lookout.
- Jacob Hoff - the chemist that got addicted to chems in Fallout: New Vegas.
- Whitney Jacobs - a mentioned-only soldier who died during the First Battle of Hoover Dam in Fallout: New Vegas.
- Warren Jacobs - a cut character in Fallout: New Vegas.
- Jacob (Fallout: New Vegas) - a former Van Graff thug in Fallout: New Vegas
- Jacob Forsythe, the doctor of Vault 81 in Fallout 4.
- Jacob Orden, the mayor of Covenant in Fallout 4.
- Jacob White, a member of the Bar Harbor Bowling League, mentioned in the Fallout 4 add-on Far Harbor.
- Jacob Young - a Coldwater ghoul in Fallout Tactics.
- Jacob (Van Buren) - an undevote mormon in Van Buren.
- Jacobstown - a location in Fallout: New Vegas.
- Jacob's scrapheap - .... in Van Buren.
- Real-life people
- John Jacobs - ....
- Karel Jacobs - ....
- Daniel Jacobs - ....
- Jakob Stalnaker - the voice actor of the young Butch DeLoria, Robert Joseph MacCready and Jason Grant in Fallout 3.
- Jacob Craner - a developer who worked at Obsidian Entertainment as a dialogue editor for Fallout: New Vegas.
- Regi Jacob - ....
- Jacobstown terminals, the terminal entries of Jacobstown in Fallout: New Vegas.
- Jacob Humboldt's dialogue, the dialogue file for Jacob Humboldt in Fallout 3 add-on in Point Lookout.
- Jacob Hoff's dialogue, the dialogue file for Jacob Hoff in Fallout: New Vegas.
- Jacob Forsythe's dialogue, the dialogue file for Jacob Forsythe in Fallout 4.
- Jacob Orden's dialogue, the dialogue file for Jacob Orden in Fallout 4.