When the October 23, 2077 drill began, the beta alert was soon upgraded to alpha and the Great War came. Due to the Overseer's sabotage, none of the science staff received a notification about the drill. However, three researchers showed up: Kenneth Collins and Jim Flint reached the Vault from the Fens with the general population, while the overachiever M. Burrow was already on site. They reported to the research area and were sealed inside. This meant that the danger to the residential population still existed.
Although there were only three of them, ensuring that the generations-long research plan would die out, they had state of the art equipment, centuries' worth of supplies, and the Contagions Vulnerability Robotic Infirmary Engineer, meaning that with even their limited manpower, they could still be a threat to the residential population. To compensate, Collins upgraded and modified Curie, from a customized Miss Nanny, into a fully fledged lab assistant. He provided her with a custom personality, loading the databanks with every great body of work he had to make her more life-like, more... Human. And so, CVRIE became Curie. With her help, the work picked up the pace and quite soon, the Phase I trials began. When notified of it, Olivette was mortified and played for time, while maintaining an aura of camaraderie, taking care to not reveal his intentions. While the mood among the three researchers remained stable thanks to Collins and Curie, they still had access to the nozzles and could release the pathogens for a Stage III trial - or worse. When a minor mishap with the mole rat population was resolved and stage II was progressing rapidly, Olivette made the decision.
The Overseer personally sabotaged the delivery nozzles inside every residential quarter and room on their side of the Vault. Then, when the researchers began to notice (Burrow, specifically), they disconnected the only terminal that could communicate with the science team and dumped it in the reactor chamber, near the sealed backup entrance into the science section. Sealed in the research wing, the scientists grimly continued their work, never to see the light of day again.
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Curie would become their inheritor, watching as they fell one-by-one. Flint was killed when a mole rat named Clyde escaped his cage. Then Collins and finally Burrow, both dying of old age. She interred them and continued the work. Finally, in 2204, Curie finally finished the broad-spectrum cure that would be capable of curing every pathogen developed and analyzed in the captive mole rats.
Jim Flint is mentioned only in Fallout 4.
- Vault 81 terminals, Old Overseers Terminal, The Day
- Vault 81 terminals, Old Overseers Terminal, Science Staff
- Vault 81 terminals, Terminal, Vault 81 Mission Statement
- Vault 81 terminals; Curie's Terminal, Boot Up
- Vault 81 terminals; Curie's Terminal, Personality Profile
- Vault 81 terminals; Research Comm Terminal, Phase I Trial
- Vault 81 terminals; Old Overseers Terminal, They Suspect
- Vault 81 terminals; Old Overseers Terminal, Forgiveness
- Vault 81 terminals; Curie's Terminal, Therapeutic
- Vault 81 terminals; Old Overseers Terminal, Please Answer
- The Sole Survivor: "These mole rats carry a disease. Do you know anything about it?"
Curie: "My poor little darlings. They were used to grow all manner of new and interesting pathogens. Then vault citizens would be exposed to these viruses in the hopes that they would develop new antibodies. But they never got a chance to execute their plan. Clyde got out of his cage. He was smarter than the others, my sweet Clyde. He let out the others and those poor scientists never stood a chance. Clyde's been dead for almost two centuries now, but his descendants have free run of the vault. I'm rambling. Where are my manners. Are you Vault-tec security?"
- Vault 81 terminals; Curie's Terminal, EULOGY
- Amari: "Think of a strong memory. The first that comes to mind. Tell me about it."
Curie: "*sigh* Doctor Burrow was very old. He was the last living scientist in my section of Vault 81. He was on his bed. Very weak. He said to me, "Curie, you must..." And he died before he finished the sentence. Oh, my insides feel peculiar. What is that?"
(Amari's and Curie's dialogue) Note: This is an excerpt from the review of the body swap procedure at the end of the quest Emergent Behavior.
- Curie: "Oh. Another stranger. Are you Vault-Tec security? I've waited so very patiently for you to arrive."
The Sole Survivor: "Yes. Yes, I am."
Curie: "Superb! I placed an emergency call so long ago. I was beginning to think something dreadful must've happened. I am pleased to report I completed my primary duties 83 years ago. Thousands of pathogens were grown in the mole rat hosts. Then a single broad spectrum cure was developed to treat them all. Very satisfying work for many decades. Now, please tell me you are authorized to release me from the lab."