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Lewis may refer to:
- Lewis, a former resident of Vault 101, mentioned in Fallout 3.
- Floyd Lewis, an engineer in Vault 101 in Fallout 3.
- Chomps Lewis, the foreman of the Quarry Junction workers in Fallout: New Vegas.
- Melissa Lewis, a Great Khan who serves as a scout in Fallout: New Vegas.
- Lewis, mentioned in the Fallout 76 add-on Wild Appalachia.
- Lewis, a scientist of Vault 0 mentioned in Fallout Tactics: Brotherhood of Steel.
- James Lewis, a voice actor who worked on Fallout 3.
- Mitch Lewis, the voice actor who voiced Legate Lanius in Fallout: New Vegas.
- John Lewis, a developer design intern who worked at Obsidian Entertainment on the Fallout: New Vegas and its add-ons.
- Lewis's personal log, a holotape in Fallout 76.
- Lewis & Sons Farming Supply, a farming supply company and a location in Fallout 76.
- Chomps Lewis' dialogue, the dialogue file for Chomps Lewis in Fallout: New Vegas.
- Melissa Lewis' dialogue, the dialogue file for Melissa Lewis in Fallout: New Vegas.
- Lewis MKII, a light-machine gun - originally of US origin and British usage, in Fallout Tactics: Brotherhood of Steel.