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Silver Geckos, called little geckos in game, are the easiest of them to kill. They appear quite early in the game. (already in the Fallout 2 Quest - Rescue Nagor's dog, Smoke, from the wilds., where they roam the Arroyo Hunting Grounds) They can be skinned, if you have the Gecko Skinning perk.
Little geckos have horrible detection AI, and it is often possible for the player to walk right in front of them and not be noticed. This makes it easy to get inside attack range without being caught. While it has been suggested that little geckos attack only when provoked, this is not true.
Little geckos will eat any iguana-on-a-stick or jerky dropped on the floor. They will also equip weapons like spiked knuckles and power fists!