|For the random encounter in Fallout 3, see Mad Brahmin Rampage.|
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Mad Brahmins is a special encounter in Fallout 2 in which you meet a herd of mad brahmin that come running towards you. These brahmin explode on contact, making them very dangerous to unprepared players, especially at low levels. It's a good idea to enter combat mode and run for the exit grid.
Behind the scenes
This is probably a reference to mad-cow disease.