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Margaret may refer to:
- Margaret Primrose, the proprietor of the Café Beau Monde in Fallout 3.
- Margaret, Three Dog's unseen technician at Galaxy News Radio. She can be heard in Fallout 3.
- Margaret Wallace, an American citizen who was abducted by the Zetan aliens, mentioned in the Fallout 3 add-on Mothership Zeta.
- Margaret Wang, a soldier who fought and died, during the First Battle of Hoover Dam. She is mentioned in Fallout: New Vegas.
- Margaret Sutton, is the deceased daughter of Bill and Mary Sutton, mentioned in Fallout 4.
- Margaret, a former resident of the Sandy Coves Convalescent Home, mentioned in Fallout 4.