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Living before the Great War, Megan, her husband Kevin, sons Ryan, Brandon, Logan, daughters Molly Anna, Kayla, and infant Brenna were all designated to live in Vault 114. Their family, the O'Briens, were assigned to the Residency B3 section of the vault. However with Vault 114's unending construction they may not have been there when the bombs hit Boston.
Megan O'Brien is mentioned only in Fallout 4.