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Murphy may refer to:
- Murphy - a chemist and drug dealer responsible for Ultrajet, in Fallout 3.
- Mama Murphy, a chem charged psyker, restaurateur and survivor of the Quincy Massacre in Fallout 4.
- "Beans" Murphy - a salvager in Denver, that was to appear in Van Buren.
- J. Hardy Murphy - an adventurer mentioned in the The Armageddon Rag.