Piers, manager of the REPCONN headquarters until 2077, was in close contact with RobCo Industries after REPCONN was bought out. He aided RobCo in performing a hostile takeover by eliminating REPCONN's founder and long time CEO Leonard Steeple with the aid of Julia Masters.
He appears to have died under a collapsed roof after attempting to escape the building with a suitcase full of money.
- In addition to a key which allows access to new areas of the building, his briefcase contains 200 stacks of pre-War money.
Piers Isley is mentioned only in Fallout: New Vegas.