- Major characters
- The Chosen One · Tandi · Joanne Lynette · Dick Richardson · Frank Horrigan · Ken Lee · AHS-9 · Harold
- Dogmeat · John Cassidy · K-9 · Marcus · Myron · Skynet · Sulik
- Major factions
- Enclave · New California Republic
- Minor factions
- Brotherhood of Steel · Hubologists · New Khans · Shi
The Rangers are given exceptional leeway and flexibility to deal with both the intrusion of organized crime and the operation of slavers near the borders of NCR territory. The Rangers are said to have numerous safehouses throughout the wastes, and they use these to strike at slavers outside of NCR territory (usually in the North). As expected, the two groups hate each other with a passion. NCR Rangers typically have bounties on their head, even in NCR states.
The game takes place in the year 2241 on the West Coast of what used to be the United States of America, mostly in California and Nevada. Faced with the worst drought on record, the village elders of Arroyo ask the direct descendant of the Vault Dweller, referred to as the Chosen One, to retrieve a Garden of Eden Creation Kit (GECK) for Arroyo.