Unfortunately, leakage from the Rocky Mountain Arsenal (a nearby toxic waste dump/weapons storage location) caused a poisonous cloud that killed a lot of people in Denver. As an apology, the military funded a program to create a self-sustaining research dome, capable of withstanding a nuclear attack. This "city of the future" was to be a prototype for settlements on the moon and other planets. After the War, the Boulder Dome is still standing in midst of the blasted remains of the city, poisoned by radiation and toxic waste. Inside the dome is a desperate team of scientists infected with a strange disease and trying to keep their ZAX unit from cannibalizing it memory to such an extent that it stops working. Beset by glowing ghouls and a large pack of cannibal primitives, the dome faces extinction.
The game would have taken place in the year 2253 in the American Southwest. The Prisoner, the player character, awakens in a prison cell. Suddenly the floor rocks violently from an explosion and the player is knocked unconscious. When they awaken, they find their cell door open and a hole in the wall leading outside. Leaving the prison, the character is under attack by some unknown assailant. Deciding that discretion is the better part of valor, the player flees into the night to explore this new world.