A citizen of Malden, Massachusetts, the Cobbs made their home in the West Everett Estates. As a construction worker, he was working with the construction crew in the neighborhood and in his free time he was working on the Nuka Cola machine in the den. When the Great War struck he and the rest of the workers were irradiated, leaving him the only survivor; and a ghoul.
When his neighbor Wayne Tournquist emerged from their shelter the night of January 27th, 2078 he went to the Cobb's home in search for duct tape, their supply exhausted. Their plan to tap into the main from the water tower worked, but the piping took more tape than expected and was leaking pretty bad. Wayne must not have heard Ron over the distant gunfire and explosions. To Wayne's surprise there was a cold gun barrel pushed up against the back of his head. Ron told Wayne to turn around slowly, and he was shocked by his ne appearance. Wayne begged him to stop, but he put the gun in his mouth and cocked back the hammer. He heard the gunshot, but when Wayne opened his eyes, Ron was falling to the ground, and Wayne spotted Lance Ames from down the street up on Wayne's roof. Lance saw the whole thing and saved Wayne's life.
Ron Cobb is mentioned only in Fallout 4.