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Rose may refer to:
- Rose, the owner of Rose's Bed and Breakfast in Modoc in Fallout 2.
- Woodrose, the tribal matriarch of the Point Lookout tribals in the Fallout 3 add-on, Point Lookout.
- Rose, a prostitute from Nipton mentioned in Fallout: New Vegas.
- Rose of Sharon Cassidy, a merchant and recruitable NPC in Fallout: New Vegas.
- Rose, a Miss Nanny character in Fallout 76.
- Jeffrey Rose, an attorney who counselled Obsidian Entertainment while they were working on Fallout: New Vegas.
- Rose Gomez, an environmental design intern developer who worked on Fallout: New Vegas.