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From The Vault - Fallout Wiki
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The Secret Vault is Vault-Tec's private vault, where its members intended to survive the apocalypse and later enter the world having all the useful technologies possible. It was located under the ghoul town of Los. The Vault serves as a major research and production facility and, among its many technological artifacts, housed a special version of Forced Evolutionary Virus.

Some time after the war, the Secret Vault was torn apart by a local civil war between Vault-Tec scientists and Blake, the chief security officer, who believed the researches with FEV and radiation, conducted on living subjects, including humans, are "evil". Their battles led to a major explosion that devastated a large portion of the Vault and enabled some species of radroaches and Deathclaws, native to the Vault, escape into the wasteland, at the same time allowing radscorpions and rats invade the Vault. CALIX also suffered a malfunction, and lost control over majority of the security robots.