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Los is a ghoul city in Texas that covers a dock area and a heavily damaged bridge.

It is inhabited by ghoul fanatics known as the Church of the Lost, who kill all humans who wander into the city limits and even kidnap some for their bloody rituals. The leader of this cult is Blake, a horror and an astonishment, a powerful, but insane ghoul warrior. The cult itself is very dangerous, as they use poison dogs, laser weapons and suicide bombers to defeat their enemies. However, not all Los ghouls are bloodthirsty killers and some are not part of cult. Some of them are friendly and live on the western part of the city's bridge. The ghouls of Los manage a Gladiator Pit, an arena where anyone can fight for money and the crowd's entertainment. The Secret Vault built by Vault-Tec for top secret Forced Evolutionary Virus research can be found under Los. It is a holy mission of Blake and his cult to protect this Vault, as they consider it to hold an evil inside that should never be released.