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Frank Horrigan is the Enclave's finest instrument of warfare. Originally a Secret Service Agent for the President of the Enclave, Frank is sent out with several other teams to search for slaves to use for excavating the remains of Mariposa in 2236, sometime between July and August. In September, scientists unearth the F.E.V. virus and mutations begin to occur amongst those who come in contact with it. Horrigan is one of these unfortunate souls. He is quickly shuttled back to the Enclave for further research.
The timeline is unknown, but between 2236 and 2238 Frank Horrigan undergoes his transformation into a Super Mutant. He is kept under heavy sedation and is operated on by Enclave technicians. In January of 2239, tests are starting to show negative results. It is then decided that Frank should be activated for field operations.