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Gwen may refer to:
- Characters:
- Gwen (Fallout), a member of the Khans and assistant to Garl Death-Hand in Fallout.
- Gwen McNamara, the overseer of Vault 81 in the Commonwealth in Fallout 4.
- V81 GwenMcNamara.txt, dialogue for Gwen McNamara in Fallout 4.
- Gwen (Fallout 4), a person who died in the Commonwealth, mentioned in Fallout 4.
- Gwen Upton, a pre-War robbery victim, mentioned in Fallout 4.
- Real-life person:
- Gwen McGee, an actress who voiced various female characters in Fallout: New Vegas.