- Major characters
- The Chosen One · Tandi · Joanne Lynette · Dick Richardson · Frank Horrigan · Ken Lee · AHS-9 · Harold
- Dogmeat · John Cassidy · K-9 · Marcus · Myron · Skynet · Sulik
- Major factions
- Enclave · New California Republic
- Minor factions
- Brotherhood of Steel · Hubologists · New Khans · Shi
In the short term, he seeks to build an alliance between Gecko and Vault City based on power from Gecko being sent to Vault City in exchange for medical research on how to "restore" the ghouls to humanity. The cult is symbolized by the ankh, and its members wear ankh necklaces. The renewal cultists seek to "renew," i.e. become human again.
The game takes place in the year 2241 on the West Coast of what used to be the United States of America, mostly in California and Nevada. Faced with the worst drought on record, the village elders of Arroyo ask the direct descendant of the Vault Dweller, referred to as the Chosen One, to retrieve a Garden of Eden Creation Kit (GECK) for Arroyo.